Vitamin D (1,25(OH)2D3) induces &#945;-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10.

Dimeloe, Sarah; Rice, Louise V; Chen, Hebe; Cheadle, Charlotte; Raynes, John; Pfeffer, Paul; Lavender, Paul; Richards, David F; Nyon, Mun Peak; McDonnell, James M; Kemper, Claudia; Gooptu, Bibek; Hawrylowicz, Catherine M

Vitamin D (1,25(OH)₂D3) induces α-1-antitrypsin synthesis by CD4⁺ T cells, which is required for 1,25(OH)₂D3-driven IL-10.

Dimeloe, Sarah; Rice, Louise V; Chen, Hebe; Cheadle, Charlotte; Raynes, John; Pfeffer, Paul; Lavender, Paul; Richards, David F; Nyon, Mun Peak; McDonnell, James M; Kemper, Claudia; Gooptu, Bibek; Hawrylowicz, Catherine M.

Afiliação

Dimeloe S; MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom.
Rice LV; MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom.
Chen H; MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom.
Cheadle C; MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom.
Raynes J; Immunology and Infection Department, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom.
Pfeffer P; MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom.
Lavender P; MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom.
Richards DF; MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom.
Nyon MP; Institute of Structural and Molecular Biology/Crystallography, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, United Kingdom.
McDonnell JM; MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom.
Kemper C; MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom.
Gooptu B; MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom; Institute of Structural and Molecular Biology/Crystallography, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London, WC1E 7HX
Hawrylowicz CM; MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom. Electronic address: catherine.hawrylowicz@kcl.ac.uk.

J Steroid Biochem Mol Biol ; 189: 1-9, 2019 05.

Article em En | MEDLINE | ID: mdl-30690074

Assuntos

Linfócitos T CD4-Positivos/efeitos dos fármacos; Calcitriol/farmacologia; Interleucina-10/imunologia; Vitaminas/farmacologia; alfa 1-Antitripsina/imunologia; Linfócitos T CD4-Positivos/imunologia; Células Cultivadas; Humanos; Fatores Imunológicos/farmacologia

Palavras-chave

C3a; Complement; IL-10; Immune regulation; α-1-Antitrypsin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitaminas / Calcitriol / Linfócitos T CD4-Positivos / Alfa 1-Antitripsina / Interleucina-10 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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