Nuclear pore density controls heterochromatin reorganization during senescence.
Genes Dev
; 33(3-4): 144-149, 2019 02 01.
Article
em En
| MEDLINE
| ID: mdl-30692205
ABSTRACT
During oncogene-induced senescence (OIS), heterochromatin is lost from the nuclear periphery and forms internal senescence-associated heterochromatin foci (SAHFs). We show that an increased nuclear pore density during OIS is responsible for SAHF formation. In particular, the nucleoporin TPR is necessary for both formation and maintenance of SAHFs. Loss of SAHFs does not affect cell cycle arrest but abrogates the senescence-associated secretory phenotype-a program of inflammatory cytokine gene activation. Our results uncover a previously unknown role of nuclear pores in heterochromatin reorganization in mammalian nuclei and demonstrate the importance of heterochromatin organization for a specific gene activation program.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Heterocromatina
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Proteínas Proto-Oncogênicas
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Senescência Celular
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Poro Nuclear
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Complexo de Proteínas Formadoras de Poros Nucleares
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article