Apolipoprotein E Polymorphism and Oxidative Stress in Peripheral Blood-Derived Macrophage-Mediated Amyloid-Beta Phagocytosis in Alzheimer's Disease Patients.

Jairani, P S; Aswathy, P M; Krishnan, Dhanya; Menon, Ramsekhar N; Verghese, Joe; Mathuranath, P S; Gopala, Srinivas

Jairani, P S; Aswathy, P M; Krishnan, Dhanya; Menon, Ramsekhar N; Verghese, Joe; Mathuranath, P S; Gopala, Srinivas.

Afiliação

Jairani PS; Cognition & Behavioral Neurology Section, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram, Kerala, India.
Aswathy PM; Cognition & Behavioral Neurology Section, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram, Kerala, India.
Krishnan D; Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram, Kerala, 695011, India.
Menon RN; Cognition & Behavioral Neurology Section, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram, Kerala, India.
Verghese J; Department of Neurology, Albert Einstein College of Medicine, New York, NY, USA.
Mathuranath PS; Cognition & Behavioral Neurology Section, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram, Kerala, India.
Gopala S; Department of Neurology, National Institute of Mental Health & Neuro Sciences (NIMHANS), Bangalore, India.

Cell Mol Neurobiol ; 39(3): 355-369, 2019 Apr.

Article em En | MEDLINE | ID: mdl-30694418

Assuntos

Doença de Alzheimer/sangue; Doença de Alzheimer/genética; Peptídeos beta-Amiloides/metabolismo; Apolipoproteínas E/genética; Macrófagos/patologia; Estresse Oxidativo; Fagocitose; Polimorfismo Genético; Idoso; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/patologia; Estudos de Casos e Controles; Diferenciação Celular/efeitos dos fármacos; Disfunção Cognitiva/patologia; Curcumina/farmacologia; Curcumina/uso terapêutico; Dano ao DNA; Endocitose/efeitos dos fármacos; Fluorescência; Humanos; Lisossomos/efeitos dos fármacos; Lisossomos/metabolismo; Monócitos/efeitos dos fármacos; Monócitos/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Fagocitose/efeitos dos fármacos; Células THP-1

Palavras-chave

APO E; Alzheimer's disease; Amyloid beta; Colocalization; Curcumin; Internalization; Macrophages; Mild cognitive impairment; Monocytes; Phagocytosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Fagocitose / Polimorfismo Genético / Peptídeos beta-Amiloides / Estresse Oxidativo / Doença de Alzheimer / Macrófagos Tipo de estudo: Observational_studies Limite: Aged / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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