Comprehensive and combined omics analysis reveals factors of ischemia-reperfusion injury in liver transplantation.
Epigenomics
; 11(5): 527-542, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30700158
ABSTRACT
AIM:
To explore molecular mechanisms underlying liver ischemia-reperfusion injury (IRI). MATERIALS &METHODS:
Four Gene Expression Omnibus datasets comprising liver transplantation data were collected for a comprehensive analysis. A proteomic analysis was performed and used for correlations analysis with transcriptomic. RESULTS &CONCLUSION:
Ten differentially expressed genes were co-upregulated in four Gene Expression Omnibus datasets, including ATF3, CCL4, DNAJB1, DUSP5, JUND, KLF6, NFKBIA, PLAUR, PPP1R15A and TNFAIP3. The combined analysis demonstrated ten coregulated genes/proteins, including HBB, HBG2, CA1, SLC4A1, PLIN2, JUNB, HBA1, MMP9, SLC2A1 and PADI4. The coregulated differentially expressed genes and coregulated genes/proteins formed a tight interaction network and could serve as the core factors underlying IRI. Comprehensive and combined omics analyses revealed key factors underlying liver IRI, and thus having potential clinical significance.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traumatismo por Reperfusão
/
Transplante de Fígado
/
Proteoma
/
Transcriptoma
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article