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A new model of the mechanism underlying lead poisoning: SNP in miRNA target region influence the AGT expression level.
Wu, Yu; Wang, Miaomiao; Zhang, Jinlong; Sun, Na; Li, Chunping.
Afiliação
  • Wu Y; 1Wuxi Medical School, Jiangnan University, 499 Jincheng Rd, Wuxi, 214023 People's Republic of China.
  • Wang M; Department of Occupational Health, Wuxi Center for Disease Control and Prevention, Wuxi, China.
  • Zhang J; Department of Occupational Health, Wuxi Center for Disease Control and Prevention, Wuxi, China.
  • Sun N; Department of Occupational Health, Wuxi Center for Disease Control and Prevention, Wuxi, China.
  • Li C; Department of Occupational Health, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Hereditas ; 156: 6, 2019.
Article em En | MEDLINE | ID: mdl-30700972
BACKGROUND: To determine if the rs7079 polymorphism located in the 3' UTR of the angiotensinogen gene (AGT) altered AGT gene expression and the risk of lead poisoning. A case-control study and luciferase reporter gene assay identified a significant association between rs7079 variants and the risk of lead poisoning. RESULTS: Serum AGT levels were significantly higher in individuals carrying the rs7079 CA genotype, as compared to those carrying the rs7079 CC genotype. The binding of the miRNA mimics miR-31-5p and miR-584-5p to the 3' UTR of AGT differed based on which rs7079 variant was present, implying that AGT gene expression depends on the rs7079 variant carried. CONCLUSIONS: The rs7079 C to A substitution reduced the binding of miR-31-5p/miR-584-5p to the 3' UTR of AGT, possibly altering the risk of lead poisoning.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Angiotensinogênio / MicroRNAs / Intoxicação por Chumbo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Angiotensinogênio / MicroRNAs / Intoxicação por Chumbo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article