Fluoride and azide binding to ferric human hemoglobin:haptoglobin complexes highlights the ligand-dependent inequivalence of the &#945; and ß hemoglobin chains.

Ascenzi, Paolo; di Masi, Alessandra; De Simone, Giovanna; Gioia, Magda; Coletta, Massimo

Fluoride and azide binding to ferric human hemoglobin:haptoglobin complexes highlights the ligand-dependent inequivalence of the α and ß hemoglobin chains.

Ascenzi, Paolo; di Masi, Alessandra; De Simone, Giovanna; Gioia, Magda; Coletta, Massimo.

Afiliação

Ascenzi P; Interdepartmental Laboratory for Electron Microscopy, Roma Tre University, Via della Vasca Navale 79, 00146, Roma, Italy. ascenzi@uniroma3.it.
di Masi A; Department of Sciences, Roma Tre University, Viale Marconi 446, 00146, Roma, Italy.
De Simone G; Department of Sciences, Roma Tre University, Viale Marconi 446, 00146, Roma, Italy.
Gioia M; Department of Clinical Sciences and Translational Medicine, University of Roma "Tor Vergata", Via Montpellier 1, 00133, Roma,, Italy.
Coletta M; Interuniversity Consortium for the Research on the Chemistry of Metals in Biological Systems, Via Celso Ulpiani 27, 70126, Bari, Italy.

J Biol Inorg Chem ; 24(2): 247-255, 2019 03.

Article em En | MEDLINE | ID: mdl-30706146

Assuntos

Azidas/química; Compostos Férricos/química; Fluoretos/química; Haptoglobinas/química; Hemoglobinas/química; Sítios de Ligação; Humanos; Cinética; Ligantes; Modelos Moleculares; Termodinâmica

Palavras-chave

Azide binding; Fluoride binding; Human haptoglobin 1-1:hemoglobin complex; Human haptoglobin 2-2:hemoglobin complex; Kinetics; Thermodynamics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azidas / Haptoglobinas / Hemoglobinas / Compostos Férricos / Fluoretos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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