Generation of induced pluripotent stem cells (iPSCs) from patient with Cri du Chat Syndrome.
Stem Cell Res
; 35: 101393, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30711802
ABSTRACT
The Cri du Chat Syndrome (CdCS) is a genetic disease resulting from variable size deletion occurring on the short arm of chromosome 5. The main clinical features are a high-pitched monochromatic cry, microcephaly, severe psychomotor and mental retardation with characteristics of autism spectrum disorders such as hand flapping, obsessive attachments to objects, twirling objects, repetitive movements, and rocking. We reprogrammed to pluripotency peripheral blood mononuclear cells derived from a patient carrying large deletion on the short arm of chromosome 5, using a commercially available non-integrating expression system. The iPSCs expressed pluripotency markers and differentiated in the three embryonic germ layers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucócitos Mononucleares
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Síndrome de Cri-du-Chat
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Células-Tronco Pluripotentes Induzidas
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Técnicas de Reprogramação Celular
Limite:
Adult
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Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article