Gastrointestinal stromal tumors. A clinicopathological study.
Saudi Med J
; 40(2): 126-130, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30723856
ABSTRACT
OBJECTIVES:
To evaluate the clinical presentations and immunohistochemical (IHC) properties of gastrointestinal stromal tumors (GISTs) and to compare them to internationally published data.METHODS:
Thirty-six patients diagnosed with GISTs between January 1997 and December 2015 were retrospectively studied in 2 tertiary hospitals. Immunohistochemical staining was carried out prospectively when it has not been completed fully at the beginning.Results:
The median age of patients was 54 years (range; 17-81 years). Predominantly, we found more females were affected. The male to female ratio was 11.7. The most frequently affected organs were the stomach (63.8%) followed by small bowel (25%) and colorectal region (8.4%). Abdominal pain was the most frequent presentation in 33.3% of the patients then gastrointestinal (GI) bleeding in 30.5%. Most of the gastric GISTs were at early stages at presentation stage 1 and II (60.8%), while in non-gastric GISTs, the tumor stage was advanced stage III and IV (69.3%). The IHC characteristic of GIST in descending order showed positivity for vimentin (88.9%), CD117 (83.3%), CD34 (77.8%), Ki67 (63.9%), SMA (38.9%), desmin (27.8%), and S100 (19.4%).CONCLUSION:
Gastrointestinal stromal tumors in our study demonstrates a major similar feature as the published international data. However, minor differences do exist in terms of clinical features and immunohistochemistry.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor Abdominal
/
Tumores do Estroma Gastrointestinal
/
Neoplasias Gastrointestinais
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Hemorragia Gastrointestinal
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article