Synthesis and anti-tumor activity study of water-soluble PEG-celastrol coupling derivatives as self-assembled nanoparticles.

Shan, Wei-Guang; Wang, Han-Guang; Wu, Rui; Zhan, Zha-Jun; Ma, Lie-Feng

Shan, Wei-Guang; Wang, Han-Guang; Wu, Rui; Zhan, Zha-Jun; Ma, Lie-Feng.

Afiliação

Shan WG; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China.
Wang HG; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China.
Wu R; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China.
Zhan ZJ; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China. Electronic address: zjnpr@zjut.edu.cn.
Ma LF; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China; Zhejiang Xinguang Pharmaceutical Limited Liability Company, Shaoxing 312400, PR China. Electronic address: maliefeng@zjut.edu.cn.

Bioorg Med Chem Lett ; 29(5): 685-687, 2019 03 01.

Article em En | MEDLINE | ID: mdl-30728110

Assuntos

Antineoplásicos/síntese química; Antineoplásicos/farmacologia; Nanopartículas/química; Polietilenoglicóis/química; Triterpenos/química; Linhagem Celular Tumoral; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Triterpenos Pentacíclicos; Solubilidade; Água/química

Palavras-chave

Antitumor; Celastrol; Nanoparticle; Self-assembly

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Triterpenos / Nanopartículas / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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