Synthesis and Fabrication of Surface-Active Microparticles Using a Membrane Emulsion Technique and Conjugation of Model Protein via Strain-Promoted Azide-Alkyne Click Chemistry in Physiological Conditions.
Bioconjug Chem
; 30(3): 531-535, 2019 03 20.
Article
em En
| MEDLINE
| ID: mdl-30730698
ABSTRACT
The rapid surface immobilization of protein on monodispersed polyester microcarriers is reported. A model protein, functionalized with a dibenzocyclooctyne core, immobilizes on the surface of azide-terminal polycaprolactone microcarriers within 10 min compared to 12 h for other conjugation techniques, and it is conducted in physiological conditions and in the absence of coupling reagents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliésteres
/
Azidas
/
Proteínas Imobilizadas
/
Química Click
/
Albumina Sérica Humana
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article