Design and synthesis of novel dual-cyclic RGD peptides for αvß3 integrin targeting.
Bioorg Med Chem Lett
; 29(7): 896-900, 2019 04 01.
Article
em En
| MEDLINE
| ID: mdl-30732943
ABSTRACT
The specific binding of RGD cyclic peptide with integrin αvß3 attracts great research interest for tumor-targeting drug delivery. Herein, we designed and synthesized a series of dual-ring RGD-peptide derivatives as a drug carrier for αvß3 targeting. Three novel peptides showed excellent cell adhesion inhibition effect, in which, P3 exhibited 7-fold enhancement in IC50 compared with cyclo(RGDfK). Drug-loaded cytotoxicity experiment and imaging experiment indicated that such dual-cyclic RGD peptides have good tumor targeting effects. This work provides a new strategy for the design of novel RGD peptides.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Integrina alfaVbeta3
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article