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Choline acetyltransferase-expressing T cells are required to control chronic viral infection.
Cox, Maureen A; Duncan, Gordon S; Lin, Gloria H Y; Steinberg, Benjamin E; Yu, Lisa X; Brenner, Dirk; Buckler, Luke N; Elia, Andrew J; Wakeham, Andrew C; Nieman, Brian; Dominguez-Brauer, Carmen; Elford, Alisha R; Gill, Kyle T; Kubli, Shawn P; Haight, Jillian; Berger, Thorsten; Ohashi, Pamela S; Tracey, Kevin J; Olofsson, Peder S; Mak, Tak W.
Afiliação
  • Cox MA; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Duncan GS; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Lin GHY; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Steinberg BE; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Yu LX; Department of Anesthesia, University of Toronto, Toronto, ON M5G 1E2, Canada.
  • Brenner D; Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON M5T 3H7, Canada.
  • Buckler LN; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Elia AJ; Department of Infection and Immunity, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg.
  • Wakeham AC; Odense Research Center for Anaphylaxis (ORCA), Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
  • Nieman B; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Dominguez-Brauer C; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Elford AR; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Gill KT; Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON M5T 3H7, Canada.
  • Kubli SP; Ontario Institute for Cancer Research and Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C1, Canada.
  • Haight J; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Berger T; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Ohashi PS; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Tracey KJ; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Olofsson PS; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Mak TW; The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
Science ; 363(6427): 639-644, 2019 02 08.
Article em En | MEDLINE | ID: mdl-30733420
Although widely studied as a neurotransmitter, T cell-derived acetylcholine (ACh) has recently been reported to play an important role in regulating immunity. However, the role of lymphocyte-derived ACh in viral infection is unknown. Here, we show that the enzyme choline acetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induced in both CD4+ and CD8+ T cells during lymphocytic choriomeningitis virus (LCMV) infection in an IL-21-dependent manner. Deletion of Chat within the T cell compartment in mice ablated vasodilation in response to infection, impaired the migration of antiviral T cells into infected tissues, and ultimately compromised the control of chronic LCMV clone 13 infection. Our results reveal a genetic proof of function for ChAT in T cells during viral infection and identify a pathway of T cell migration that sustains antiviral immunity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colina O-Acetiltransferase / Interleucinas / Linfócitos T CD8-Positivos / Coriomeningite Linfocítica Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colina O-Acetiltransferase / Interleucinas / Linfócitos T CD8-Positivos / Coriomeningite Linfocítica Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article