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Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs.
Dell'Omo, Giulia; Crescenti, Daniela; Vantaggiato, Cristina; Parravicini, Chiara; Borroni, Aurora Paola; Rizzi, Nicoletta; Garofalo, Mariangela; Pinto, Andrea; Recordati, Camilla; Scanziani, Eugenio; Bassi, Fabio Domenico; Pruneri, Giancarlo; Conti, Paola; Eberini, Ivano; Maggi, Adriana; Ciana, Paolo.
Afiliação
  • Dell'Omo G; Department of Oncology and Hemato-Oncology, University of Milan, 20133, Milan, Italy.
  • Crescenti D; Department of Oncology and Hemato-Oncology, University of Milan, 20133, Milan, Italy.
  • Vantaggiato C; Department of Oncology and Hemato-Oncology, University of Milan, 20133, Milan, Italy.
  • Parravicini C; Department of Pharmacological and Biomolecular Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133, Milan, Italy.
  • Borroni AP; Department of Oncology and Hemato-Oncology, University of Milan, 20133, Milan, Italy.
  • Rizzi N; Department of Pharmacological and Biomolecular Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133, Milan, Italy.
  • Garofalo M; Department of Oncology and Hemato-Oncology, University of Milan, 20133, Milan, Italy.
  • Pinto A; Department of Pharmaceutical Sciences, University of Milan, 20133, Milan, Italy.
  • Recordati C; Mouse & Animal Pathology Lab, Fondazione Filarete, 20139, Milan, Italy.
  • Scanziani E; Mouse & Animal Pathology Lab, Fondazione Filarete, 20139, Milan, Italy.
  • Bassi FD; Division of Breast Surgery, European Institute of Oncology Milan, 20141, Milan, Italy.
  • Pruneri G; Department of Oncology and Hemato-Oncology, University of Milan, 20133, Milan, Italy.
  • Conti P; Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133, Milan, Italy.
  • Eberini I; Department of Pharmaceutical Sciences, University of Milan, 20133, Milan, Italy.
  • Maggi A; Department of Pharmacological and Biomolecular Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133, Milan, Italy.
  • Ciana P; Department of Pharmacological and Biomolecular Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133, Milan, Italy.
Br J Cancer ; 120(5): 537-546, 2019 03.
Article em En | MEDLINE | ID: mdl-30739913
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulindaco / Anti-Inflamatórios não Esteroides / Proteína Supressora de Tumor p53 / Inibidores de Ciclo-Oxigenase / Anticarcinógenos / Inibidor de Quinase Dependente de Ciclina p21 / Sirtuína 1 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulindaco / Anti-Inflamatórios não Esteroides / Proteína Supressora de Tumor p53 / Inibidores de Ciclo-Oxigenase / Anticarcinógenos / Inibidor de Quinase Dependente de Ciclina p21 / Sirtuína 1 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article