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Perineural invasion is related to p38 mitogen-activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer.
Gu, Jiangning; Xu, Wei; Peng, Chenghong; Zhu, Youwei; Wang, Di; Wang, Xuelong; Li, Ying; Wei, Gang; Zhang, Zhiqiang; Zhong, Yiming; Zhao, Shulin; Shi, Minmin; Cheng, Dongfeng; Ying, Xiayang; Jin, Jiabin; Chen, Hao.
Afiliação
  • Gu J; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Xu W; Research Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Peng C; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Zhu Y; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Wang D; Research Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Wang X; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Li Y; Research Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Wei G; Department of Scientific Research, Eyes & ENT Hospital of Fudan University, Shanghai, China.
  • Zhang Z; Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Zhong Y; Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Zhao S; Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Shi M; Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Cheng D; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Ying X; Research Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Jin J; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Chen H; Research Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
J Cell Biochem ; 120(7): 11775-11783, 2019 Jul.
Article em En | MEDLINE | ID: mdl-30756419
ABSTRACT
Metastasis is a key component of cancer progression and is strongly associated with poor prognosis. Perineural invasion is thought to be related to pain, tumor recurrence, and other conditions. However, the exact molecular mechanism is unclear. This study was conducted to identify the key components and signaling pathways involved in the perineural invasion of pancreatic cancer and alterations in the phenotype after the interaction between the dorsal root ganglion (DRG) and pancreatic cancer cells. The results indicated that the p38 mitogen-activated protein kinase signaling pathway was activated after coculture of the DRG and pancreatic cancer cells and lead to the promotion of cell growth and chemoresistance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article