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Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation.
Minata, Mutsuko; Audia, Alessandra; Shi, Junfeng; Lu, Songjian; Bernstock, Joshua; Pavlyukov, Marat S; Das, Arvid; Kim, Sung-Hak; Shin, Yong Jae; Lee, Yeri; Koo, Harim; Snigdha, Kirti; Waghmare, Indrayani; Guo, Xing; Mohyeldin, Ahmed; Gallego-Perez, Daniel; Wang, Jia; Chen, Dongquan; Cheng, Peng; Mukheef, Farah; Contreras, Minerva; Reyes, Joel F; Vaillant, Brian; Sulman, Erik P; Cheng, Shi-Yuan; Markert, James M; Tannous, Bakhos A; Lu, Xinghua; Kango-Singh, Madhuri; Lee, L James; Nam, Do-Hyun; Nakano, Ichiro; Bhat, Krishna P.
Afiliação
  • Minata M; Department of Neurosurgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
  • Audia A; Department of Translational Molecular Pathology and Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Shi J; Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA.
  • Lu S; Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Bernstock J; Medical Scientist Training Program, The University of Alabama at Birmingham, Birmingham, AL, USA.
  • Pavlyukov MS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russian Federation.
  • Das A; Department of Translational Molecular Pathology and Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Kim SH; Department of Animal Science, Chonnam National University, Gwangju 61186, Korea.
  • Shin YJ; Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Health Science & Technology, Samsung Advanced Institute for Health Science & Technology, Sungkyunkwan University, Seoul, Korea.
  • Lee Y; Institute for Refractory Cancer Research, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Koo H; Institute for Refractory Cancer Research, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Snigdha K; Department of Biology, Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH, USA.
  • Waghmare I; Department of Biology, Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH, USA.
  • Guo X; Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, China; Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.
  • Mohyeldin A; Department of Neurosurgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
  • Gallego-Perez D; Department of Surgery, The Ohio State University, Columbus, OH, USA; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
  • Wang J; Department of Neurosurgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
  • Chen D; Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
  • Cheng P; Department of Neurosurgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
  • Mukheef F; Department of Translational Molecular Pathology and Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Contreras M; Department of Translational Molecular Pathology and Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Reyes JF; Department of Translational Molecular Pathology and Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Vaillant B; Department of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
  • Sulman EP; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Cheng SY; The Ken & Ruth Davee Department of Neurology & Northwestern Brain Tumor Institute, Center for Genetic Medicine, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Markert JM; Department of Neurosurgery, The University of Alabama at Birmingham, Birmingham, AL, USA.
  • Tannous BA; Experimental Therapeutics and Molecular Imaging Lab, Department of Neurology, Neuro-oncology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Lu X; Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Kango-Singh M; Department of Biology, Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH, USA.
  • Lee LJ; Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA.
  • Nam DH; Institute for Refractory Cancer Research, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Health Science & Technology, Samsung Advanced In
  • Nakano I; Department of Neurosurgery, The University of Alabama at Birmingham, Birmingham, AL, USA; Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: inakano@uabmc.edu.
  • Bhat KP; Department of Translational Molecular Pathology and Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: kbhat@mdanderson.org.
Cell Rep ; 26(7): 1893-1905.e7, 2019 02 12.
Article em En | MEDLINE | ID: mdl-30759398
ABSTRACT
Unresectable glioblastoma (GBM) cells in the invading tumor edge can act as seeds for recurrence. The molecular and phenotypic properties of these cells remain elusive. Here, we report that the invading edge and tumor core have two distinct types of glioma stem-like cells (GSCs) that resemble proneural (PN) and mesenchymal (MES) subtypes, respectively. Upon exposure to ionizing radiation (IR), GSCs, initially enriched for a CD133+ PN signature, transition to a CD109+ MES subtype in a C/EBP-ß-dependent manner. Our gene expression analysis of paired cohorts of patients with primary and recurrent GBMs identified a CD133-to-CD109 shift in tumors with an MES recurrence. Patient-derived CD133-/CD109+ cells are highly enriched with clonogenic, tumor-initiating, and radiation-resistant properties, and silencing CD109 significantly inhibits these phenotypes. We also report a conserved regulation of YAP/TAZ pathways by CD109 that could be a therapeutic target in GBM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radiação Ionizante / Adaptação Fisiológica / Glioma Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radiação Ionizante / Adaptação Fisiológica / Glioma Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article