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Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.
Zhang, Yong-Jie; Guo, Lin; Gonzales, Patrick K; Gendron, Tania F; Wu, Yanwei; Jansen-West, Karen; O'Raw, Aliesha D; Pickles, Sarah R; Prudencio, Mercedes; Carlomagno, Yari; Gachechiladze, Mariam A; Ludwig, Connor; Tian, Ruilin; Chew, Jeannie; DeTure, Michael; Lin, Wen-Lang; Tong, Jimei; Daughrity, Lillian M; Yue, Mei; Song, Yuping; Andersen, Jonathan W; Castanedes-Casey, Monica; Kurti, Aishe; Datta, Abhishek; Antognetti, Giovanna; McCampbell, Alexander; Rademakers, Rosa; Oskarsson, Björn; Dickson, Dennis W; Kampmann, Martin; Ward, Michael E; Fryer, John D; Link, Christopher D; Shorter, James; Petrucelli, Leonard.
Afiliação
  • Zhang YJ; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Guo L; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA.
  • Gonzales PK; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Gendron TF; Department of Integrative Physiology, Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
  • Wu Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Jansen-West K; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA.
  • O'Raw AD; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Pickles SR; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Prudencio M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Carlomagno Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Gachechiladze MA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Ludwig C; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA.
  • Tian R; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Chew J; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • DeTure M; Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, and Chan Zuckerberg Biohub, San Francisco, CA, USA.
  • Lin WL; Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, and Chan Zuckerberg Biohub, San Francisco, CA, USA.
  • Tong J; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Daughrity LM; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA.
  • Yue M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Song Y; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA.
  • Andersen JW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Castanedes-Casey M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Kurti A; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Datta A; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Antognetti G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • McCampbell A; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Rademakers R; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Oskarsson B; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Dickson DW; Protein Chemistry, Biogen Idec, Cambridge, MA, USA.
  • Kampmann M; Protein Chemistry, Biogen Idec, Cambridge, MA, USA.
  • Ward ME; Neurology Research, Biogen Idec, Cambridge, MA, USA.
  • Fryer JD; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
  • Link CD; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA.
  • Shorter J; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
  • Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Science ; 363(6428)2019 02 15.
Article em En | MEDLINE | ID: mdl-30765536
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA de Cadeia Dupla / Heterocromatina / Dipeptídeos / Proteína C9orf72 / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA de Cadeia Dupla / Heterocromatina / Dipeptídeos / Proteína C9orf72 / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article