Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation.

Hillert, Ellin-Kristina; Brnjic, Slavica; Zhang, Xiaonan; Mazurkiewicz, Magdalena; Saei, Amir Ata; Mofers, Arjan; Selvaraju, Karthik; Zubarev, Roman; Linder, Stig; D'Arcy, Padraig

Hillert, Ellin-Kristina; Brnjic, Slavica; Zhang, Xiaonan; Mazurkiewicz, Magdalena; Saei, Amir Ata; Mofers, Arjan; Selvaraju, Karthik; Zubarev, Roman; Linder, Stig; D'Arcy, Padraig.

Afiliação

Hillert EK; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Brnjic S; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Zhang X; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Mazurkiewicz M; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Saei AA; Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Mofers A; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Selvaraju K; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Zubarev R; Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Linder S; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
D'Arcy P; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. Electronic address: padraig.darcy@liu.se.

Cancer Lett ; 448: 70-83, 2019 04 28.

Article em En | MEDLINE | ID: mdl-30768956

Assuntos

Piperidonas/farmacologia; Inibidores de Proteassoma/farmacologia; Proteólise/efeitos dos fármacos; Apoptose/efeitos dos fármacos; Bortezomib/farmacologia; Morte Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Neoplasias do Colo/metabolismo; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Inibidores de Histona Desacetilases/farmacologia; Humanos; Piperidonas/uso terapêutico; Complexo de Endopeptidases do Proteassoma/efeitos dos fármacos; Ubiquitina/metabolismo

Palavras-chave

Deubiquitinase; UPS inhibitor; Ubiquitin-proteasome system

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidonas / Proteólise / Inibidores de Proteassoma Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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