Comparison of intravenous lidocaine/ketorolac combination to either analgesic alone for suspected renal colic pain in the ED.
Am J Emerg Med
; 38(2): 165-172, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-30770244
ABSTRACT
STUDY OBJECTIVE:
To compare analgesic efficacy and safety of intravenous lidocaine and ketorolac combination to each analgesic alone for ED patients with suspected renal colic.METHODS:
We conducted a randomized, double-blind trial comparing analgesic efficacy of a combination of intravenous lidocaine (1.5â¯mg/kg) and ketorolac (30â¯mg), to ketorolac (30â¯mg), and to lidocaine (1.5â¯mg/kg) in patients aged 18-64 presenting to the ED with suspected renal colic. Primary outcome included difference in pain scores between the groups at 30â¯min. Secondary outcomes included a comparative reduction in pain scores in each group from baseline to 30 and 60â¯min as well as rates of adverse events and need for rescue analgesia at 30 and 60â¯min.RESULTS:
We enrolled 150 subjects (50 per group). The difference in mean pain scores at 30â¯min between Lidocaine and Lidocaine/Ketorolac groups was -2.89 (95% CI -4.39 to -1.39); between Ketorolac and Lidocaine/Ketorolac group was -0.92 (95% CI -2.44 to 0.61); and between Ketorolac and Lidocaine was -1.98 (95% CI -3.69 to -0.27). A comparative percentage of subjects in each group required rescue analgesia at 30 and 60â¯min. No clinically concerning changes in vital signs were observed. No serious adverse events occurred in either group. Commonly reported adverse effects were dizziness, nausea, and headache.CONCLUSION:
The administration of intravenous lidocaine/ketorolac combination to ED patients with suspected renal colic results in better analgesia in comparison to lidocaine alone but provides no analgesic advantages over ketorolac alone. Clinicaltrials.gov Registration NCT02902770.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cetorolaco
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Combinação de Medicamentos
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Cólica Renal
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Lidocaína
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article