Challenges and Solutions in Multimodal Medical Image Subregion Detection and Registration.

BACKGROUND: The automatic detection of common subregions and registration in multimodal functional and structural images is challenging. This article gives an overview of multimodal image registration and the developments and technical issues with automatic detection and registration of subregions of interest in multimodal images. DISCUSSION: The available knowledge about subregion detection and registration in multimodal images are described in detail. Besides the provision of compact knowledge on subregion detection and registration, the challenges and proposed solutions are also discussed. CONCLUSION: This article provides research guidelines for the development of automatic detection and registration of subregions of interest in functional and structural images with high accuracy and efficiency.