Butyrate Makes Macrophages "Go Nuclear" against Bacterial Pathogens.

Lobel, Lior; Garrett, Wendy S

Lobel, Lior; Garrett, Wendy S.

Afiliação

Lobel L; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA.
Garrett WS; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA. Electronic address: wgarrett@hsph.harvard.edu.

Immunity ; 50(2): 275-278, 2019 02 19.

Article em En | MEDLINE | ID: mdl-30784572

ABSTRACT

ABSTRACT

Butyrate is a microbial metabolite with pleiotropic effects. Schulthess et al. (2019) report that butyrate preconditioning of macrophages enhances their anti-bacterial preparedness by inducing anti-microbial proteins that restrict bacterial growth. This study augments understanding of how microbial metabolites shape host defense.

Assuntos

Anti-Infecciosos; Butiratos; Antibacterianos; Ácidos Graxos Voláteis; Macrófagos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Butiratos / Anti-Infecciosos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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