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Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay.
Seo, Ji-Eun; Tryndyak, Volodymyr; Wu, Qiangen; Dreval, Kostiantyn; Pogribny, Igor; Bryant, Matthew; Zhou, Tong; Robison, Timothy W; Mei, Nan; Guo, Xiaoqing.
Afiliação
  • Seo JE; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR, 72079, USA.
  • Tryndyak V; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, 72079, USA.
  • Wu Q; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, 72079, USA.
  • Dreval K; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, 72079, USA.
  • Pogribny I; Department of Internal Medicine, Division of Molecular Medicine, Program in Cancer Genetics, Epigenetics and Genomics, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, 87131, USA.
  • Bryant M; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, 72079, USA.
  • Zhou T; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, 72079, USA.
  • Robison TW; Center for Veterinary Medicine, U.S. Food and Drug Administration, Rockville, MD, 20855, USA.
  • Mei N; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA.
  • Guo X; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR, 72079, USA.
Arch Toxicol ; 93(5): 1433-1448, 2019 05.
Article em En | MEDLINE | ID: mdl-30788552
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Carcinógenos / Ensaio Cometa / Mutagênicos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Carcinógenos / Ensaio Cometa / Mutagênicos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article