Activated neutrophil carbamylates albumin <i>via</i> the release of myeloperoxidase and reactive oxygen species regardless of NETosis.

Nakabo, Shuichiro; Ohmura, Koichiro; Akizuki, Shuji; Murakami, Kosaku; Nakashima, Ran; Hashimoto, Motomu; Yoshifuji, Hajime; Tanaka, Masao; Mimori, Tsuneyo

Activated neutrophil carbamylates albumin via the release of myeloperoxidase and reactive oxygen species regardless of NETosis.

Nakabo, Shuichiro; Ohmura, Koichiro; Akizuki, Shuji; Murakami, Kosaku; Nakashima, Ran; Hashimoto, Motomu; Yoshifuji, Hajime; Tanaka, Masao; Mimori, Tsuneyo.

Afiliação

Nakabo S; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ohmura K; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Akizuki S; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Murakami K; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nakashima R; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hashimoto M; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yoshifuji H; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tanaka M; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Mimori T; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Mod Rheumatol ; 30(2): 345-349, 2020 Mar.

Article em En | MEDLINE | ID: mdl-30789095

Assuntos

Albuminas/metabolismo; Artrite Reumatoide/metabolismo; Armadilhas Extracelulares/metabolismo; Peroxidase/metabolismo; Carbamilação de Proteínas; Espécies Reativas de Oxigênio/metabolismo; Células Cultivadas; Humanos; Neutrófilos/metabolismo

Palavras-chave

Anti-carbamylated protein antibodies; anti-modified protein antibodies; autoantibodies; neutrophils; rheumatoid arthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Espécies Reativas de Oxigênio / Peroxidase / Albuminas / Armadilhas Extracelulares / Carbamilação de Proteínas Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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