Ivabradine reversed nondipping heart rate in rats with l-NAME-induced hypertension.
Clin Exp Pharmacol Physiol
; 46(6): 607-610, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30790319
ABSTRACT
We hypothesized that decreasing elevated night-time heart rate (HR) in hypertension by administering a bradycardic agent (ivabradine) at bedtime could bring cardiovascular benefit. Since rats are nocturnal animals, they exhibit circadian rhythms phase-shifted relative to humans. Sixty-six Wistar rats were divided into non-diseased controls and rats with l-NAME-induced hypertension to compare the haemodynamic effects of daytime-dosed and night-time-dosed ivabradine. l-NAME-induced hypertension inverted the physiological 5.6% night-to-day HR dip to an undesirable HR rise by 11.1%. Ivabradine dosed at daytime (the rat's resting phase) reverted a night-to-day HR rise to HR dip by 14.2%. These results suggest a cardiovascular benefit of ivabradine dosed at the human's resting phase (night-time) for hypertensive patients with nondipping HR.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
NG-Nitroarginina Metil Éster
/
Ivabradina
/
Frequência Cardíaca
/
Hipertensão
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article