BCL-3 promotes a cancer stem cell phenotype by enhancing ß-catenin signalling in colorectal tumour cells.

Legge, Danny N; Shephard, Alex P; Collard, Tracey J; Greenhough, Alexander; Chambers, Adam C; Clarkson, Richard W; Paraskeva, Christos; Williams, Ann C

Legge, Danny N; Shephard, Alex P; Collard, Tracey J; Greenhough, Alexander; Chambers, Adam C; Clarkson, Richard W; Paraskeva, Christos; Williams, Ann C.

Afiliação

Legge DN; Colorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Faculty of Life Sciences, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, UK.
Shephard AP; Colorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Faculty of Life Sciences, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, UK.
Collard TJ; Colorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Faculty of Life Sciences, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, UK.
Greenhough A; Colorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Faculty of Life Sciences, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, UK.
Chambers AC; Centre for Research in Biosciences, Faculty of Health and Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK.
Clarkson RW; Colorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Faculty of Life Sciences, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, UK.
Paraskeva C; European Cancer Stem Cell Research Institute, Hadyn Ellis Building, Maindy Road, Cathays, Cardiff CF24 4HQ, UK.
Williams AC; Colorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Faculty of Life Sciences, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, UK.

Dis Model Mech ; 12(3)2019 03 04.

Article em En | MEDLINE | ID: mdl-30792270

Assuntos

Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia; Proteínas Proto-Oncogênicas/metabolismo; Fatores de Transcrição/metabolismo; Via de Sinalização Wnt; Proteína 3 do Linfoma de Células B; Linhagem Celular Tumoral; Núcleo Celular/metabolismo; Regulação Neoplásica da Expressão Gênica; Genes Reporter; Humanos; Fator 1 de Ligação ao Facilitador Linfoide/metabolismo; Fenótipo; Ligação Proteica; Transporte Proteico; Proteínas Proto-Oncogênicas/genética; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Esferoides Celulares/metabolismo; Esferoides Celulares/patologia; Fatores de Transcrição TCF/metabolismo; Fatores de Transcrição/genética; beta Catenina/metabolismo

Palavras-chave

ASCL2; BCL3; LGR5; NF-kappaB; NF-κB; Spheroid; Wnt

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Células-Tronco Neoplásicas / Neoplasias Colorretais / Proteínas Proto-Oncogênicas / Via de Sinalização Wnt Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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