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The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel.
De Logu, Francesco; Li Puma, Simone; Landini, Lorenzo; Tuccinardi, Tiziano; Poli, Giulio; Preti, Delia; De Siena, Gaetano; Patacchini, Riccardo; Tsagareli, Merab G; Geppetti, Pierangelo; Nassini, Romina.
Afiliação
  • De Logu F; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.
  • Li Puma S; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.
  • Landini L; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.
  • Tuccinardi T; Department of Pharmacy, University of Pisa, Pisa, Italy.
  • Poli G; Department of Pharmacy, University of Pisa, Pisa, Italy.
  • Preti D; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy.
  • De Siena G; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.
  • Patacchini R; Department of Corporate Drug Development, Chiesi Farmaceutici SpA, Parma, Italy.
  • Tsagareli MG; Laboratory of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.
  • Geppetti P; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.
  • Nassini R; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy. Electronic address: romina.nassini@unifi.it.
Pharmacol Res ; 142: 127-139, 2019 04.
Article em En | MEDLINE | ID: mdl-30794923
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Anti-Inflamatórios não Esteroides / Ibuprofeno / Canal de Cátion TRPA1 / Glucuronatos / Hiperalgesia / Analgésicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Anti-Inflamatórios não Esteroides / Ibuprofeno / Canal de Cátion TRPA1 / Glucuronatos / Hiperalgesia / Analgésicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article