Trends in contact lens microbial keratitis 1999 to 2015: a retrospective clinical review.
Clin Exp Ophthalmol
; 47(6): 726-732, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-30801907
ABSTRACT
IMPORTANCE Contact lens microbial keratitis (CLMK) is the most common cause of microbial keratitis in our community. BACKGROUND:
Define the trend in rate of CLMK and define patient demographics/culture results that may have a predictive value in patients with CLMK.DESIGN:
Retrospective review of clinical records of patients with MK.PARTICIPANTS:
All patients with positive corneal scraping between 1999 and 2015 at the Princess Alexandra Hospital, Brisbane, Queensland identified through local microbiology database.METHODS:
Trend in CLMK tested with chi-squared test of peak 3 years vs other years and Poisson regression of interrupted time series. Patient characteristics predictive of CLMK were defined by creating a polynomial regression model by stepwise variable selection. MAIN OUTCOMEMEASURES:
Yearly rate of CLMK.RESULTS:
Records of 895 episodes of MK were included. The most common risk factor was contact lens wear (324, 36.2%), isolated organism was Pseudomonas aeruginosa (P. aeruginosa 181, 55.9%) and treatment was monotherapy with a fluoroquinolone 172, 53%). CLMK was most common between 2009 and 2011 (49.5% vs other years 32%, P < 0.001). Poisson regression of the interrupted time series showed there was a significant decrease in the rate over time after 2010 (P < 0.001). Independent factors predictive of CLMK in multivariate regression were young age (15-49 years) and corneal culture positive for P. aeruginosa CONCLUSIONS AND RELEVANCE The rate of CLMK in our community ranged between 32% and 50% and the rate of disease appears to have peaked during 2009 to 2011 and subsequently declined.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Oculares Bacterianas
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Infecções Oculares Fúngicas
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Úlcera da Córnea
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Lentes de Contato
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
País/Região como assunto:
Oceania
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article