Re-irradiation of locally recurrent pediatric intracranial ependymoma: Experience of the French society of children's cancer.
Radiother Oncol
; 132: 1-7, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30825956
ABSTRACT
PURPOSE:
This study aimed to evaluate retrospectively the clinical results of re-irradiation for children with a locally recurrent brain ependymoma.METHODS:
33 full-dose re-irradiations were delivered to 31 children with a recurrent brain ependymoma after a standard treatment. Each child was followed up with clinical and MRI examinations. We evaluated overall survival, local recurrence free-survival and short term toxicity according to CTCAE 4.0 scale.RESULTS:
With a median follow-up of 37â¯months (range, 0 to 107), median local recurrence free-survival was 31â¯months (range, 2 to 63) and median overall survival was 34â¯months (range, 3 to 63). It was significantly higher in patients who underwent surgery first, compared with re-irradiation only. Cumulated dosimetric data were available for 22 patients. On average, maximal BED to brain stem was 106,2â¯Gyα/ß3 (±35,4) for infratentorial re-irradiation. No acute toxicity grade >2 was reported and 1 case of brain radionecrosis treated successfully with steroids was reported after radiosurgery.CONCLUSION:
Local recurrence of brain ependymoma can be treated with full-dose re-irradiation, which can be hypofractionated with an acceptable short term toxicity in spite of high total doses delivered to OARs, especially brain stem.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Ependimoma
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Recidiva Local de Neoplasia
Tipo de estudo:
Etiology_studies
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Observational_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article