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Maternal betaine status, but not that of choline or methionine, is inversely associated with infant birth weight.
Du, Yu-Feng; Wei, Yuan; Yang, Jing; Cheng, Zi-Yi; Zuo, Xi-Fang; Wu, Tian-Chen; Shi, Hui-Feng; Wang, Xiao-Li.
Afiliação
  • Du YF; Department of Maternal and Child Health,School of Public Health,Peking University,Beijing 100191,People's Republic of China.
  • Wei Y; Obstetrics and Gynecology Department,Peking University Third Hospital,Beijing100191,People's Republic of China.
  • Yang J; Obstetrics and Gynecology Department,Peking University Third Hospital,Beijing100191,People's Republic of China.
  • Cheng ZY; Obstetrics and Gynecology Department,Peking University Third Hospital,Beijing100191,People's Republic of China.
  • Zuo XF; Obstetrics and Gynecology Department,Tongzhou Maternal and Child Health Hospital of Beijing,Beijing101101,People's Republic of China.
  • Wu TC; Department of Maternal and Child Health,School of Public Health,Peking University,Beijing 100191,People's Republic of China.
  • Shi HF; Department of Maternal and Child Health,School of Public Health,Peking University,Beijing 100191,People's Republic of China.
  • Wang XL; Department of Maternal and Child Health,School of Public Health,Peking University,Beijing 100191,People's Republic of China.
Br J Nutr ; 121(11): 1279-1286, 2019 06.
Article em En | MEDLINE | ID: mdl-30837009
ABSTRACT
Maternal one-carbon metabolism during pregnancy is crucial for fetal development and programming by DNA methylation. However, evidence on one-carbon biomarkers other than folate is lacking. We, therefore, investigated whether maternal plasma methyl donors, that is, choline, betaine and methionine, are associated with birth outcomes. Blood samples were obtained from 115 women during gestation (median 26·3 weeks, 90 % range 22·7-33·0 weeks). Plasma choline, betaine, methionine and dimethylglycine were measured using HPLC-tandem MS. Multivariate linear and logistic regression models were used to estimate the association between plasma biomarkers and birth weight, birth length, the risk of small-for-gestational-age and large-for-gestational-age (LGA). Higher level of maternal betaine was associated with lower birth weight (-130·3 (95 % CI -244·8, -15·9) per 1 sd increment for log-transformed betaine). Higher maternal methionine was associated with lower risk of LGA, and adjusted OR, with 95 % CI for 1 sd increase in methionine concentration was 0·44 (95 % CI 0·21, 0·89). Stratified analyses according to infant sex or maternal plasma homocysteine status showed that reduction in birth weight in relation to maternal betaine was only limited to male infants or to who had higher maternal homocysteine status (≥5·1 µmol/l). Higher maternal betaine status was associated with reduced birth weight. Maternal methionine was inversely associated with LGA risk. These findings are needed to be replicated in future larger studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trimestres da Gravidez / Betaína / Peso ao Nascer / Fenômenos Fisiológicos da Nutrição Materna Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trimestres da Gravidez / Betaína / Peso ao Nascer / Fenômenos Fisiológicos da Nutrição Materna Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article