Controlling Nutritional Status (CONUT) as a prognostic immunonutritional biomarker for gastric cancer after curative gastrectomy: a propensity score-matched analysis.
Surg Endosc
; 33(12): 4143-4152, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-30838449
ABSTRACT
BACKGROUND:
In clinical practice, it is not unusual to treat oncologic patients whose tumor markers are within normal range, even with advanced cancer. The Controlling Nutritional Status (CONUT) score could provide a useful nutritional and immunological prognostic biomarker for cancer patients. In this study, we assessed the prognostic value of the CONUT score for patients with gastric cancer, including a subgroup analysis with stratification based on serum carcinoembryonic antigen (CEA) level.METHODS:
We retrospectively reviewed the medical records of 368 consecutive patients who underwent curative laparoscopy-assisted gastrectomy. The prognostic value of the CONUT score was compared between patients with a low (≤ 2) and high (≥ 3) score, with propensity score matching (PSM) used to control for biasing covariates (Depth of tumor, Lymph node metastasis, pathological TNM (pTNM) stage).RESULTS:
Overall survival (OS) among all patients was independently predicted by the tumor stage (hazard ratio (HR) 2.231, p = 0.001), the CONUT score (HR 2.254, p = 0.001), and serum CEA level (HR 1.821, p = 0.025). Among patients with a normal preoperative serum CEA level, tumor stage (HR 2.350, p = 0.007), and the CONUT score (HR 1.990, p = 0.028) were independent prognostic factors of OS. In the high serum CEA level group, tumor size (HR 2.930, p = 0.015) and the CONUT score (HR 3.707, p = 0.004) were independent prognostic factors of OS.CONCLUSIONS:
It is advantageous to use both CEA level and the CONUT score to assess the prognosis of patients with gastric cancer, which reflect both tumor-related factors and host-related factors, respectively.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Antígeno Carcinoembrionário
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Gastrectomia
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article