FLOT1 promotes tumor development, induces epithelial-mesenchymal transition, and modulates the cell cycle by regulating the Erk/Akt signaling pathway in lung adenocarcinoma.

Zhang, Louqian; Mao, Yuan; Mao, Qixing; Fan, Weifei; Xu, Li; Chen, Yan; Xu, Lin; Wang, Jun

Zhang, Louqian; Mao, Yuan; Mao, Qixing; Fan, Weifei; Xu, Li; Chen, Yan; Xu, Lin; Wang, Jun.

Afiliação

Zhang L; Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China.
Mao Y; The Fourth Clinical College of Nanjing Medical University, Nanjing, China.
Mao Q; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing, China.
Fan W; Department of Hematology and Oncology, Department of Geriatric Lung Cancer Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province Geriatric Hospital, Nanjing, China.
Xu L; Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China.
Chen Y; The Fourth Clinical College of Nanjing Medical University, Nanjing, China.
Xu L; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing, China.
Wang J; Department of Hematology and Oncology, Department of Geriatric Lung Cancer Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province Geriatric Hospital, Nanjing, China.

Thorac Cancer ; 10(4): 909-917, 2019 04.

Article em En | MEDLINE | ID: mdl-30838797

Assuntos

Adenocarcinoma de Pulmão/genética; Neoplasias Pulmonares/genética; Sistema de Sinalização das MAP Quinases; Proteínas de Membrana/genética; Células A549; Adenocarcinoma de Pulmão/metabolismo; Ciclo Celular; Proliferação de Células; Transição Epitelial-Mesenquimal; Regulação Neoplásica da Expressão Gênica; Técnicas de Silenciamento de Genes; Humanos; Neoplasias Pulmonares/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais

Palavras-chave

FLOT1; lung adenocarcinoma; malignant behavior; signaling pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema de Sinalização das MAP Quinases / Adenocarcinoma de Pulmão / Neoplasias Pulmonares / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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