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Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report.
McDonald, Vanessa M; Fingleton, James; Agusti, Alvar; Hiles, Sarah A; Clark, Vanessa L; Holland, Anne E; Marks, Guy B; Bardin, Philip P; Beasley, Richard; Pavord, Ian D; Wark, Peter A B; Gibson, Peter G.
Afiliação
  • McDonald VM; Priority Research Centre for Healthy Lungs and Centre of Excellence in Severe Asthma, Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.
  • Fingleton J; Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia.
  • Agusti A; Respiratory Medicine Dept, Capital and Coast District Health Board, Wellington, New Zealand.
  • Hiles SA; Asthma and COPD Programme, Medical Research Institute of New Zealand, Wellington, New Zealand.
  • Clark VL; Respiratory Institute, Hospital Clinic, Universitat de Barcelona, IDIBAPS, CIBERES, Barcelona, Spain.
  • Holland AE; Priority Research Centre for Healthy Lungs and Centre of Excellence in Severe Asthma, Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.
  • Marks GB; Priority Research Centre for Healthy Lungs and Centre of Excellence in Severe Asthma, Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia vanessa.mcdonald@newcastle.edu.au.
  • Bardin PP; Discipline of Physiotherapy, La Trobe University Dept of Physiotherapy, Alfred Health, Institute for Breathing and Sleep, Melbourne, Australia.
  • Beasley R; South Western Sydney Clinical School, UNSW, Sydney, Australia.
  • Pavord ID; Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
  • Wark PAB; Lung and Sleep Medicine, Monash University and Medical Centre, Clayton, Australia.
  • Gibson PG; Respiratory Medicine Dept, Capital and Coast District Health Board, Wellington, New Zealand.
Eur Respir J ; 53(5)2019 05.
Article em En | MEDLINE | ID: mdl-30846468
"Treatable traits" have been proposed as a new paradigm for the management of airway diseases, particularly complex disease, which aims to apply personalised medicine to each individual to improve outcomes. Moving new treatment approaches from concepts to practice is challenging, but necessary. In an effort to accelerate progress in research and practice relating to the treatable traits approach, the Treatable Traits Down Under International Workshop was convened in Melbourne, Australia in May 2018. Here, we report the key concepts and research questions that emerged in discussions during the meeting. We propose a programme of research that involves gaining international consensus on candidate traits, recognising the prevalence of traits, and identifying a potential hierarchy of traits based on their clinical impact and responsiveness to treatment. We also reflect on research methods and designs that can generate new knowledge related to efficacy of the treatable traits approach and consider multidisciplinary models of care that may aid its implementation into practice.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Respiratórias / Gerenciamento Clínico Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Respiratórias / Gerenciamento Clínico Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article