High-fat diet impacts more changes in beta-cell compared to alpha-cell transcriptome.

Dusaulcy, Rodolphe; Handgraaf, Sandra; Visentin, Florian; Howald, Cedric; Dermitzakis, Emmanouil T; Philippe, Jacques; Gosmain, Yvan

Dusaulcy, Rodolphe; Handgraaf, Sandra; Visentin, Florian; Howald, Cedric; Dermitzakis, Emmanouil T; Philippe, Jacques; Gosmain, Yvan.

Afiliação

Dusaulcy R; Molecular Diabetes Laboratory, Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital/Diabetes Center/University of Geneva Medical School, Geneva, Switzerland.
Handgraaf S; Molecular Diabetes Laboratory, Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital/Diabetes Center/University of Geneva Medical School, Geneva, Switzerland.
Visentin F; Molecular Diabetes Laboratory, Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital/Diabetes Center/University of Geneva Medical School, Geneva, Switzerland.
Howald C; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
Philippe J; Molecular Diabetes Laboratory, Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital/Diabetes Center/University of Geneva Medical School, Geneva, Switzerland.
Gosmain Y; Molecular Diabetes Laboratory, Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital/Diabetes Center/University of Geneva Medical School, Geneva, Switzerland.

PLoS One ; 14(3): e0213299, 2019.

Article em En | MEDLINE | ID: mdl-30849121

Assuntos

Dieta Hiperlipídica/efeitos adversos; Regulação da Expressão Gênica; Células Secretoras de Glucagon/metabolismo; Ilhotas Pancreáticas/metabolismo; Obesidade/metabolismo; Transcriptoma; Animais; Células Cultivadas; Células Secretoras de Glucagon/citologia; Ilhotas Pancreáticas/citologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Obesos; Camundongos Transgênicos; Obesidade/etiologia; Obesidade/patologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Ilhotas Pancreáticas / Células Secretoras de Glucagon / Transcriptoma / Dieta Hiperlipídica / Obesidade Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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