Reference values for leptin/adiponectin ratio in healthy children and adolescents.
Clin Chim Acta
; 493: 123-128, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-30849308
ABSTRACT
BACKGROUND:
Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios.METHODS:
Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits.RESULTS:
Nine hundred eighty-three participants (583 girls) aged 6-18â¯years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (pâ¯<â¯.001).CONCLUSION:
The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leptina
/
Adiponectina
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article