Development of tau-directed small molecule modulators for Alzheimer's disease: a recent patent review (2014-2018).

Lee, Ha E; Lim, Dami; Lee, Jae Y; Lim, Sang M; Pae, Ae N

Lee, Ha E; Lim, Dami; Lee, Jae Y; Lim, Sang M; Pae, Ae N.

Afiliação

Lee HE; Convergence Research Center for Diagnosis, Treatment & Care System of Dementia, Korea Institute of Science & Technology, Seoul 02792, Republic of Korea.
Lim D; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science & Technology, Seoul 02792, Republic of Korea.
Lee JY; Convergence Research Center for Diagnosis, Treatment & Care System of Dementia, Korea Institute of Science & Technology, Seoul 02792, Republic of Korea.
Lim SM; KHU-KIST Department of Converging Science & Technology, Kyung Hee University, Seoul 02447, Republic of Korea.
Pae AN; KHU-KIST Department of Converging Science & Technology, Kyung Hee University, Seoul 02447, Republic of Korea.

Pharm Pat Anal ; 8(1): 15-39, 2019 Jan.

Article em En | MEDLINE | ID: mdl-30870110

Assuntos

Doença de Alzheimer/tratamento farmacológico; Desenvolvimento de Medicamentos/métodos; Proteínas tau/efeitos dos fármacos; Doença de Alzheimer/fisiopatologia; Peptídeos beta-Amiloides/metabolismo; Animais; Humanos; Patentes como Assunto; Proteínas tau/metabolismo

Palavras-chave

Alzheimer's disease; aggregation; patent; post-translational modification; tau

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas tau / Doença de Alzheimer / Desenvolvimento de Medicamentos Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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