The protective effect of Costus afer Ker Gawl aqueous leaf extract on lead-induced reproductive changes in male albino Wistar rats.
JBRA Assist Reprod
; 23(3): 215-224, 2019 08 22.
Article
em En
| MEDLINE
| ID: mdl-30875184
ABSTRACT
INTRODUCTION:
Lead is a multiple organ toxicant and an oxidative-stress inducer. The effect of Costus afer on metal- induced male reprotoxicity has not been previously carried out, hence this study. The present study investigates the protective effect of Costus afer aqueous leave extract on lead- induced reproductive damages in male albino Wistar rats.METHODS:
Adult male albino Wistar rats were weighed and separated into five groups of five rats each. Groups 1 & 2 served as normal and toxic controls receiving deionized and leaded (CH3COO)2Pb.3H2O and water respectively. Groups 3, 4 and 5 were given 750, 1500 and 2250mg/kg of Costus afer orally, respectively while receiving Pb2+ water ad libitum for 28 days.RESULTS:
The reproductive and antioxidant parameters obtained from the result served as scientific evidence in the study. The result showed non-significant changes in the absolute and relative weights of epididymis and testes in the Pb Group versus the control. Significant increases were recorded in the sperm analysis, blood lead (7.9±1.02; 1.1±0.01) level (BLL), luteinizing hormone (LH) (8.5±1.45.5±0.4), and a decrease in follicle stimulating hormone (FSH) (4.5±2.66.5±1.65), with non-significant changes in testosterone (TET) (1.3±0.001.6±0.2) in the Pb group compared to the control.CONCLUSION:
The treatment with Costus afer exhibited dose-dependent significant changes in testicular oxidative stress, hormonal, sperm analysis and histopathological changes induced by lead. Aqueous leaves extract of Costus afer may be protective against lead induced testicular damage.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Substâncias Protetoras
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Costus
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Infertilidade
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Intoxicação por Chumbo
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article