Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury.

Hu, Jiangnan; Chen, Lefu; Huang, Xujun; Wu, Ke; Ding, Saidan; Wang, Weikan; Wang, Brian; Smith, Charity; Ren, Changhong; Ni, Haoqi; ZhuGe, Qichuan; Yang, Jianjing

Hu, Jiangnan; Chen, Lefu; Huang, Xujun; Wu, Ke; Ding, Saidan; Wang, Weikan; Wang, Brian; Smith, Charity; Ren, Changhong; Ni, Haoqi; ZhuGe, Qichuan; Yang, Jianjing.

Afiliação

Hu J; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. hu.jiangnan@hotmail.com.
Chen L; Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA. hu.jiangnan@hotmail.com.
Huang X; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Wu K; Department of Intensive Care Unit (ICU), Hengdian Wenrong Hospital, Jinhua, 322100, China.
Ding S; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Wang W; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Wang B; Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
Smith C; Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
Ren C; Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
Ni H; Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
ZhuGe Q; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Yang J; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. zhugeqichuan@vip.163.com.

Stem Cell Res Ther ; 10(1): 96, 2019 03 15.

Article em En | MEDLINE | ID: mdl-30876457

Assuntos

Células da Medula Óssea/metabolismo; Lesões Encefálicas Traumáticas; Calpaína/antagonistas & inibidores; Dipeptídeos/farmacologia; Sobrevivência de Enxerto/efeitos dos fármacos; Transplante de Células-Tronco Mesenquimais; Células-Tronco Mesenquimais/metabolismo; Aloenxertos; Animais; Células da Medula Óssea/patologia; Lesões Encefálicas Traumáticas/metabolismo; Lesões Encefálicas Traumáticas/patologia; Lesões Encefálicas Traumáticas/terapia; Modelos Animais de Doenças; Masculino; Células-Tronco Mesenquimais/patologia; Ratos; Ratos Sprague-Dawley

Palavras-chave

Bone marrow-derived mesenchymal stem cells; Calpain inhibitor; MDL28170; Preconditioning; Transplantation; Traumatic brain injury

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células da Medula Óssea / Calpaína / Transplante de Células-Tronco Mesenquimais / Dipeptídeos / Células-Tronco Mesenquimais / Lesões Encefálicas Traumáticas / Sobrevivência de Enxerto Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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