Small structural alterations greatly influence the membrane affinity of lipophilic ligands: Membrane interactions of bafilomycin A<sub>1</sub> and its desmethyl derivative bearing <sup>19</sup>F-labeling.

Hayashi, Tatsuru; Tsuchikawa, Hiroshi; Umegawa, Yuichi; Murata, Michio

Small structural alterations greatly influence the membrane affinity of lipophilic ligands: Membrane interactions of bafilomycin A₁ and its desmethyl derivative bearing ¹⁹F-labeling.

Hayashi, Tatsuru; Tsuchikawa, Hiroshi; Umegawa, Yuichi; Murata, Michio.

Afiliação

Hayashi T; Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
Tsuchikawa H; Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan. Electronic address: h-tsuchi@chem.sci.osaka-u.ac.jp.
Umegawa Y; Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
Murata M; Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan. Electronic address: murata@chem.sci.osaka-u.ac.jp.

Bioorg Med Chem ; 27(8): 1677-1682, 2019 04 15.

Article em En | MEDLINE | ID: mdl-30878192

Assuntos

Membrana Celular/química; Ligantes; Macrolídeos/química; Membrana Celular/metabolismo; Permeabilidade da Membrana Celular/efeitos dos fármacos; Flúor/química; Ligação de Hidrogênio; Cinética; Macrolídeos/metabolismo; Macrolídeos/farmacologia; Espectroscopia de Ressonância Magnética

Palavras-chave

Bafilomycin; Lipophilic ligand; Membrane affinity; PAMPA; Solid-state NMR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membrana Celular / Macrolídeos / Ligantes Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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