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Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
Shirai, Fumiyuki; Tsumura, Takeshi; Yashiroda, Yoko; Yuki, Hitomi; Niwa, Hideaki; Sato, Shin; Chikada, Tsubasa; Koda, Yasuko; Washizuka, Kenichi; Yoshimoto, Nobuko; Abe, Masako; Onuki, Tetsuo; Mazaki, Yui; Hirama, Chizuko; Fukami, Takehiro; Watanabe, Hirofumi; Honma, Teruki; Umehara, Takashi; Shirouzu, Mikako; Okue, Masayuki; Kano, Yuko; Watanabe, Takashi; Kitamura, Kouichi; Shitara, Eiki; Muramatsu, Yukiko; Yoshida, Haruka; Mizutani, Anna; Seimiya, Hiroyuki; Yoshida, Minoru; Koyama, Hiroo.
Afiliação
  • Fukami T; RIKEN Program for Drug Discovery and Medical Technology Platforms , 2-1 Hirosawa , Wako , Saitama 351-0198 , Japan.
  • Muramatsu Y; Division of Molecular Biotherapy, Cancer Chemotherapy Center , Japanese Foundation for Cancer Research , 3-8-31 Ariake , Koto-ku, Tokyo 135-8850 , Japan.
  • Yoshida H; Division of Molecular Biotherapy, Cancer Chemotherapy Center , Japanese Foundation for Cancer Research , 3-8-31 Ariake , Koto-ku, Tokyo 135-8850 , Japan.
  • Mizutani A; Division of Molecular Biotherapy, Cancer Chemotherapy Center , Japanese Foundation for Cancer Research , 3-8-31 Ariake , Koto-ku, Tokyo 135-8850 , Japan.
  • Seimiya H; Division of Molecular Biotherapy, Cancer Chemotherapy Center , Japanese Foundation for Cancer Research , 3-8-31 Ariake , Koto-ku, Tokyo 135-8850 , Japan.
  • Yoshida M; Department of Biotechnology , The University of Tokyo , 1-1-1 Yayoi , Bunkyo-ku, Tokyo 113-8657 , Japan.
J Med Chem ; 62(7): 3407-3427, 2019 04 11.
Article em En | MEDLINE | ID: mdl-30883102
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Tanquirases / Inibidores Enzimáticos / Indóis Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Tanquirases / Inibidores Enzimáticos / Indóis Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article