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Structural modification of indomethacin toward selective inhibition of COX-2 with a significant increase in van der Waals contributions.
Ikeda, Akari; Funakoshi, Eishi; Araki, Mitsugu; Ma, Biao; Karuo, Yukiko; Tarui, Atsushi; Sato, Kazuyuki; Okuno, Yasushi; Kawai, Kentaro; Omote, Masaaki.
Afiliação
  • Ikeda A; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
  • Funakoshi E; Faculty of Science and Engineering, Setsunan University, 17-8 Ikedanaka-machi, Neyagawa, Osaka 573-8508, Japan.
  • Araki M; Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan.
  • Ma B; Research and Development Group for In Silico Drug Discovery, Center for Cluster Development and Coordination (CCD), Foundation for Biomedical Research and Innovation at Kobe (FBRI), 6-3-5, Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
  • Karuo Y; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
  • Tarui A; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
  • Sato K; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
  • Okuno Y; Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan.
  • Kawai K; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
  • Omote M; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address: omote@pharm.setsunan.ac.jp.
Bioorg Med Chem ; 27(9): 1789-1794, 2019 05 01.
Article em En | MEDLINE | ID: mdl-30898436
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Indometacina / Ciclo-Oxigenase 2 Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Indometacina / Ciclo-Oxigenase 2 Idioma: En Ano de publicação: 2019 Tipo de documento: Article