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Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo.
Read, Cai; Yang, Peiran; Kuc, Rhoda E; Nyimanu, Duuamene; Williams, Thomas L; Glen, Robert C; Holt, Lucy J; Arulanantham, Haren; Smart, Andrew; Davenport, Anthony P; Maguire, Janet J.
Afiliação
  • Read C; Experimental Medicine and Immunotherapeutics, Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
  • Yang P; Experimental Medicine and Immunotherapeutics, Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
  • Kuc RE; Experimental Medicine and Immunotherapeutics, Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
  • Nyimanu D; Experimental Medicine and Immunotherapeutics, Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
  • Williams TL; Experimental Medicine and Immunotherapeutics, Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
  • Glen RC; The Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK.
  • Holt LJ; Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
  • Arulanantham H; GlaxoSmithKline, Stevenage, UK.
  • Smart A; GlaxoSmithKline, Stevenage, UK.
  • Davenport AP; Severn Biotech Ltd, Kidderminster, UK.
  • Maguire JJ; Experimental Medicine and Immunotherapeutics, Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Basic Clin Pharmacol Toxicol ; 126 Suppl 6: 96-103, 2020 Jun.
Article em En | MEDLINE | ID: mdl-30901161
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Albumina Sérica / Apelina / Receptores de Apelina Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Albumina Sérica / Apelina / Receptores de Apelina Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article