Correlation of Lobar Cerebral Microbleeds with Amyloid, Perfusion, and Metabolism in Alzheimer's Disease.
J Alzheimers Dis
; 68(4): 1489-1497, 2019.
Article
em En
| MEDLINE
| ID: mdl-30909210
ABSTRACT
BACKGROUND:
Despite the well-documented relationship between lobar cerebral microbleeds (lCMB) and Alzheimer's disease (AD), there is limited knowledge about the role of lCMB in AD pathology.OBJECTIVE:
To understand the nature of this relationship, we investigated the association between lCMB, amyloid load, perfusion, and metabolism.METHODS:
Participants with AD, mild cognitive impairment (MCI), and healthy controls were recruited and scanned with 11C-Pittsburg-Compound B (PiB), Fluorodeoxyglucose (FDG) PET, and susceptibility-weighted MRI. Early PiB-PET frames were used to estimate perfusion. The association between lCMB and PET uptake in each anatomical lobe was measured using multiple regression models.RESULTS:
The presence of lCMB predicted increased total (pâ<â0.001) and regional (pâ=â0.0002) PiB uptake, as well as decreased cerebral perfusion (pâ=â0.03). Cases with lCMB had hypometabolism in their temporal lobe (pâ=â0.04).CONCLUSION:
There are significant relationships between lCMBs and various markers of AD pathology. lCMB has a spatial association with Aß load and a complex effect on perfusion and metabolism.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Hemorragia Cerebral
/
Peptídeos beta-Amiloides
/
Doença de Alzheimer
/
Disfunção Cognitiva
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Aged80
/
Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article