Strategies to Circumvent Host Innate Immune Response by Hepatitis C Virus.
Cells
; 8(3)2019 03 22.
Article
em En
| MEDLINE
| ID: mdl-30909456
ABSTRACT
Innate immune responses generate interferons, proinflammatory cytokines, complement activation, and natural killer (NK) cell response. Ultimately, this leads to the induction of a robust virus-specific adaptive immunity. Although the host innate immune system senses and responds to eliminate virus infection, hepatitis C virus (HCV) evades immune attack and establishes persistent infection within the liver. Spontaneous clearance of HCV infection is associated with a prompt induction of innate immunity generated in an infected host. In this review, we have highlighted the current knowledge of our understanding of hostâ»HCV interactions, especially for endogenous interferon production, proinflammatory response, NK cell response, and complement activation, which may impair the generation of a strong adaptive immune response for establishment of chronicity. The information may provide novel strategies in augmenting therapeutic intervention against HCV.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hepacivirus
/
Interações Hospedeiro-Patógeno
/
Imunidade Inata
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article