Polymorphs, co-crystal structure and pharmacodynamics study of MBRI-001, a deuterium-substituted plinabulin derivative as a tubulin polymerization inhibitor.

Ma, Mingxu; Ding, Zhongpeng; Wang, Shixiao; Ma, Lingling; Wang, Yuxi; Zhong, Lili; Li, Zhongping; Yang, Jinliang; Li, Wenbao

Ma, Mingxu; Ding, Zhongpeng; Wang, Shixiao; Ma, Lingling; Wang, Yuxi; Zhong, Lili; Li, Zhongping; Yang, Jinliang; Li, Wenbao.

Afiliação

Ma M; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Ding Z; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Wang S; Marine Biomedical Research Institute of Qingdao, Qingdao 266071, China.
Ma L; Precision Medicine Research Center, Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy and Cancer, Chengdu 610041, China.
Zhong L; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Li Z; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy and Cancer, Chengdu 610041, China.
Yang J; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy and Cancer, Chengdu 610041, China. Electronic address: jlyang01@163.com.
Li W; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Innovation Center for Marine Drug Screening and Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China; Marine Biomedical Research Institute of Qingdao, Qingdao 266071, China.

Bioorg Med Chem ; 27(9): 1836-1844, 2019 05 01.

Article em En | MEDLINE | ID: mdl-30910474

Assuntos

Dicetopiperazinas/química; Moduladores de Tubulina/química; Tubulina (Proteína)/química; Animais; Sítios de Ligação; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Cristalografia por Raios X; Deutério/química; Dicetopiperazinas/metabolismo; Dicetopiperazinas/farmacologia; Dicetopiperazinas/uso terapêutico; Humanos; Camundongos; Camundongos Nus; Conformação Molecular; Simulação de Dinâmica Molecular; Neoplasias/tratamento farmacológico; Estrutura Terciária de Proteína; Tubulina (Proteína)/metabolismo; Moduladores de Tubulina/metabolismo; Moduladores de Tubulina/farmacologia; Moduladores de Tubulina/uso terapêutico

Palavras-chave

Anti-cancer agent; Co-crystal structure; MBRI-001; Polymorphs; Tubulin inhibition

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tubulina (Proteína) / Moduladores de Tubulina / Dicetopiperazinas Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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