A BODIPY-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long-Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features.
Angew Chem Int Ed Engl
; 58(21): 7008-7012, 2019 05 20.
Article
em En
| MEDLINE
| ID: mdl-30912228
ABSTRACT
Bright long-wavelength-excitable semiconducting polymer dots (LWE-Pdots) are highly desirable for inâ
vivo imaging and multiplexed inâ
vitro bioassays. LWE-Pdots have been obtained by incorporating a near-infrared (NIR) emitter into the backbone of a polymer host to develop a binary donor-acceptor (D-A) system. However, they usually suffer from severe concentration quenching and a trade-off between fluorescence quantum yield (Φf ) and absorption cross-section (σ). Herein, we describe a ternary component (D1 /D2 -A) strategy to achieve ultrabright, green laser-excitable Pdots with narrow-band NIR emission by introducing a BODIPY-based assistant polymer donor as D1 . The D1 /D2 -A Pdots possess improved Φf and σ compared to corresponding binary D2 -A Pdots. Their Φf is as high as 40.2 %, one of the most efficient NIR Pdots reported. The D1 /D2 -A Pdots show ultrahigh single-particle brightness, 83-fold brighter than Qdot 705 when excited by a 532â
nm laser. When injected into mice, higher contrast inâ
vivo tumor imaging was achieved using the ternary Pdots versus the binary D-A Pdots.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Semicondutores
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Compostos de Boro
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Pontos Quânticos
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Raios Infravermelhos
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Neoplasias Experimentais
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article