Copper chaperone blocks amyloid formation via ternary complex.

Horvath, Istvan; Werner, Tony; Kumar, Ranjeet; Wittung-Stafshede, Pernilla

Horvath, Istvan; Werner, Tony; Kumar, Ranjeet; Wittung-Stafshede, Pernilla.

Afiliação

Horvath I; Department of Biology and Biological Engineering,Chalmers University of Technology,412 96 Gothenburg,Sweden.
Werner T; Department of Biology and Biological Engineering,Chalmers University of Technology,412 96 Gothenburg,Sweden.
Kumar R; Department of Biology and Biological Engineering,Chalmers University of Technology,412 96 Gothenburg,Sweden.
Wittung-Stafshede P; Department of Biology and Biological Engineering,Chalmers University of Technology,412 96 Gothenburg,Sweden.

Q Rev Biophys ; 51: e6, 2018 01.

Article em En | MEDLINE | ID: mdl-30912493

Assuntos

Amiloide/metabolismo; Cobre/metabolismo; Metalochaperonas/metabolismo; Amiloide/genética; Sítios de Ligação; Linhagem Celular; Microambiente Celular; Proteínas de Transporte de Cobre; Humanos; Modelos Moleculares; Chaperonas Moleculares; Mutação; Agregados Proteicos; Conformação Proteica; Dobramento de Proteína; alfa-Sinucleína/genética; alfa-Sinucleína/metabolismo

Palavras-chave

Alpha-synuclein; Atox1; amyloids; copper chaperone; metal transport; protein misfolding

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cobre / Metalochaperonas / Amiloide Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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