Single-cell assessment of transcriptome alterations induced by Scriptaid in early differentiated human haematopoietic progenitors during ex vivo expansion.

Hua, Peng; Kronsteiner, Barbara; van der Garde, Mark; Ashley, Neil; Hernandez, Diana; Tarunina, Marina; Hook, Lilian; Choo, Yen; Roberts, Irene; Mead, Adam; Watt, Suzanne M

Hua, Peng; Kronsteiner, Barbara; van der Garde, Mark; Ashley, Neil; Hernandez, Diana; Tarunina, Marina; Hook, Lilian; Choo, Yen; Roberts, Irene; Mead, Adam; Watt, Suzanne M.

Afiliação

Hua P; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.
Kronsteiner B; Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and NHS Blood and Transplant, John Radcliffe Hospital, Oxford, OX3 9BQ, UK.
van der Garde M; Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and NHS Blood and Transplant, John Radcliffe Hospital, Oxford, OX3 9BQ, UK.
Ashley N; Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and NHS Blood and Transplant, John Radcliffe Hospital, Oxford, OX3 9BQ, UK.
Hernandez D; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.
Tarunina M; Plasticell Ltd, Stevenage Bioscience Catalyst, Stevenage, SG1 2FX, UK.
Hook L; Plasticell Ltd, Stevenage Bioscience Catalyst, Stevenage, SG1 2FX, UK.
Choo Y; Plasticell Ltd, Stevenage Bioscience Catalyst, Stevenage, SG1 2FX, UK.
Roberts I; Plasticell Ltd, Stevenage Bioscience Catalyst, Stevenage, SG1 2FX, UK.
Mead A; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.
Watt SM; Department of Paediatrics, University of Oxford, Children's Hospital, John Radcliffe Hospital, Oxford, OX3 9DU, UK.

Sci Rep ; 9(1): 5300, 2019 03 28.

Article em En | MEDLINE | ID: mdl-30923342

Assuntos

Doenças Hematológicas/terapia; Transplante de Células-Tronco Hematopoéticas/métodos; Células-Tronco Hematopoéticas/efeitos dos fármacos; Hidroxilaminas/farmacologia; Quinolinas/farmacologia; Transcriptoma/efeitos dos fármacos; Técnicas de Cultura de Células; Diferenciação Celular/efeitos dos fármacos; Diferenciação Celular/genética; Células Cultivadas; Meios de Cultura Livres de Soro; Sangue Fetal/citologia; Células-Tronco Hematopoéticas/metabolismo; Humanos; RNA-Seq; Análise de Célula Única; Antígenos Thy-1/genética; Antígenos Thy-1/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Células-Tronco Hematopoéticas / Transplante de Células-Tronco Hematopoéticas / Transcriptoma / Doenças Hematológicas / Hidroxilaminas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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