Asymmetric Total Synthesis of Vincadifformine Enabled by a Thiourea-Phosphonium Salt Catalyzed Mannich-Type Reaction.
Chemistry
; 25(25): 6306-6310, 2019 May 02.
Article
em En
| MEDLINE
| ID: mdl-30924207
ABSTRACT
An asymmetric total synthesis of vincadifformine is described. The limited tactics with chiral cation-directed catalysis in total synthesis inspired the development of our strategy for accessing this alkaloid in enantionrich form. The route features a thiourea-phosphonium salt catalyzed Mannich-type reaction, a phosphine-promoted aza-Morita-Baylis-Hillman reaction and a trifluoroacetic acid promoted deprotection/amidation cascade process.
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Coleções:
01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article