H2 relaxin ameliorates angiotensin II-induced endothelial dysfunction through inhibition of excessive mitochondrial fission.

Gao, Lei; Liu, Yue; Wang, Ying; Chen, Wenjia; Yang, Kelaier; Li, Jiawen; Lv, Bo; Zhang, Xin; Chi, Jinyu; Liu, Na; Yin, Xinhua; Zhang, Xiaohui

Gao, Lei; Liu, Yue; Wang, Ying; Chen, Wenjia; Yang, Kelaier; Li, Jiawen; Lv, Bo; Zhang, Xin; Chi, Jinyu; Liu, Na; Yin, Xinhua; Zhang, Xiaohui.

Afiliação

Gao L; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Liu Y; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Wang Y; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Chen W; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Yang K; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Li J; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Lv B; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Zhang X; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Chi J; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Liu N; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Yin X; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China. Electronic address: yinxinhua5063@163.com.
Zhang X; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China. Electronic address: zhangxiaohui830909@163.com.

Biochem Biophys Res Commun ; 512(4): 799-805, 2019 05 14.

Article em En | MEDLINE | ID: mdl-30928096

Assuntos

Angiotensina II/metabolismo; Endotélio Vascular/efeitos dos fármacos; Dinâmica Mitocondrial/fisiologia; Relaxina/farmacologia; Angiotensina II/toxicidade; Cardiotônicos/farmacologia; Citosol/efeitos dos fármacos; Citosol/metabolismo; Dinaminas/metabolismo; Endotélio Vascular/fisiopatologia; Células Endoteliais da Veia Umbilical Humana; Humanos; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Dinâmica Mitocondrial/efeitos dos fármacos; Proteínas Mitocondriais/genética; Proteínas Mitocondriais/metabolismo; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Angiotensin II; H2 relaxin; Human umbilical vascular endothelial cells; Mitochondrial fission

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relaxina / Angiotensina II / Endotélio Vascular / Dinâmica Mitocondrial Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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