The effect of CS-514, an inhibitor of HMG-CoA reductase, on serum lipids in healthy volunteers.
Atherosclerosis
; 61(2): 125-8, 1986 Aug.
Article
em En
| MEDLINE
| ID: mdl-3092836
ABSTRACT
CS-514 is a competitive inhibitor of HMG-CoA reductase. The effect of this agent on serum lipids and lipoproteins was studied in 10 healthy normocholesterolemic male volunteers by giving 20 mg of CS-514 or placebo twice a day for 7 days under double-blind conditions. The mean total serum cholesterol level decreased by 18.6% in the CS-514 group, whereas it increased by 7.4% in the placebo group and the difference between the two groups was statistically significant (P less than 0.01). LDL cholesterol and LDL apo B values were reduced by 22.6% and 23.2%, respectively. Serum triglyceride level did not change significantly. No clinical or laboratory abnormalities were observed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Ácidos Heptanoicos
/
Lipídeos
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Naftalenos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article