ISCEV extended protocol for the stimulus-response series for light-adapted full-field ERG.
Doc Ophthalmol
; 138(3): 205-215, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30929108
ABSTRACT
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum protocol for clinical testing but encourages additional ERG testing when appropriate. This ISCEV extended protocol describes methods to record and evaluate a light-adapted (LA) ERG stimulus-response series with increasing flash strengths. The LA ERG stimulus-response series (also referred to as the luminance-response or intensity-response series in the published literature) can characterise generalised cone system function more comprehensively than the ISCEV standard LA ERGs alone. The amplitude of LA ERG a-waves, arising from cones and cone off-bipolar cells, typically shows a saturating function. The LA ERG b-wave amplitudes, which arise primarily from activity of retinal bipolar cells, show an amplitude peak followed by a nonzero plateau (the "photopic hill" phenomenon). This ISCEV extended protocol specifies a stimulus-response series suitable to evaluate generalised dysfunction affecting the LA retina, to aid in distinguishing between the on- and off-responses of the cone system and to monitor ERG changes in these characteristics. The LA ERG stimulus-response series for a- and b-waves is recorded to a sequence of nine flash stimuli ranging from 0.03 to 300 cd s m-2, superimposed on a standard background of 30 cd m-2. A shorter protocol is also presented to measure the mid-range of the function (the "photopic hill") using 5 flash stimuli.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estimulação Luminosa
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Retina
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Oftalmopatias Hereditárias
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Protocolos Clínicos
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Cegueira Noturna
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Doenças Genéticas Ligadas ao Cromossomo X
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Eletrorretinografia
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Luz
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Miopia
Tipo de estudo:
Guideline
Limite:
Adult
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article